Active Ingredient Research

Omega-3 Fatty Acids / EPA / Eicosapentaenoic Acid

Relieves Arthritis & Allergy Inflammation.

Research Overview

Eicosapentaenoic acid (EPA) is a type of omega-3 fatty acid that is found in fatty fish, such as salmon, sardines, and mackerel, as well as in some algae. There are many potential health benefits associated with EPA:

  1. Reducing inflammation: EPA has anti-inflammatory properties and can help reduce inflammation in the body, which is linked to a variety of chronic diseases, including heart disease, cancer, arthritis, and allergies in dogs.

  2. Improving joint and bone health: EPA has been shown to improve joint health and mobility in dogs with arthritis by reducing inflammation in the joints.

  3. Promoting healthy skin and coat: EPA can help maintain healthy skin and coat in dogs by reducing inflammation and improving the skin's barrier function.

  4. Help reduce metabolic syndrome associated with geriatric and Cushingoid dogs.

  5. Improving heart health: EPA may help lower triglyceride levels and reduce the risk of heart disease by reducing inflammation, improving blood vessel function, and reducing the risk of blood clots.

  6. Supporting brain health: EPA is important for brain function and may help reduce the risk of age-related cognitive decline, depression, and anxiety.

  7. Omega-3s may help improve inattention and decrease hyperactivity, impulsiveness, restlessness, and aggression.

  8. Improve eye health and KCS dry-eye symptoms.

  9. Omega-3 fatty acids may help treat and prevent several autoimmune diseases.

General Research References

Pubmed EPA Treatment Research Summary
https://pubmed.ncbi.nlm.nih.gov/?term=Eicosapentaenoic+Acid+%28EPA%29&filter=pubt.review

Muller and Kirk's Small Animal Dermatology - 9781416000280
https://www.elsevier.com/books/muller-and-kirks-small-animal-dermatology/miller/978-1-4160-0028-0

Small Animal Dermatology - 9780323376518
https://www.us.elsevierhealth.com/small-animal-dermatology-9780323376518.html

Omega-3 Fatty Acids Fact Sheet
https://ods.od.nih.gov/pdf/factsheets/omega3fattyacids-consumer.pdf

17 Science-Based Benefits of Omega-3 Fatty Acids
https://www.healthline.com/nutrition/17-health-benefits-of-omega-3

Omega-3 fatty acids EPA and DHA: health benefits throughout life
Studies have shown that EPA and DHA are important for proper fetal development, including neuronal, retinal, and immune function. EPA and DHA may affect many aspects of cardiovascular function including inflammation, peripheral artery disease, major coronary events, and anticoagulation. EPA and DHA have been linked to promising results in prevention, weight management, and cognitive function in those with very mild Alzheimer's disease. 
https://pubmed.ncbi.nlm.nih.gov/22332096/

Therapeutic Effect of EPA/DHA Supplementation in Neoplastic and Non-neoplastic Companion Animal Diseases: A Systematic Review

https://pubmed.ncbi.nlm.nih.gov/33910819/

Exploring the efficacy and optimal dosages of omega-3 supplementation for companion animals with chronic diseases

https://pubmed.ncbi.nlm.nih.gov/40495687/

Therapeutic use of fish oils in companion animals

https://pubmed.ncbi.nlm.nih.gov/22087720/

The essential nature of dietary omega-3 fatty acids in dogs

https://pubmed.ncbi.nlm.nih.gov/27875089/

Potential adverse effects of omega-3 fatty acids in dogs and cats

https://pubmed.ncbi.nlm.nih.gov/23323770/

General References

Pubmed EPA Treatment Research Summary
https://pubmed.ncbi.nlm.nih.gov/?term=Eicosapentaenoic+Acid+%28EPA%29&filter=pubt.review

Muller and Kirk's Small Animal Dermatology - 9781416000280
https://www.elsevier.com/books/muller-and-kirks-small-animal-dermatology/miller/978-1-4160-0028-0

Small Animal Dermatology - 9780323376518
https://www.us.elsevierhealth.com/small-animal-dermatology-9780323376518.html

Omega-3 Fatty Acids Fact Sheet
https://ods.od.nih.gov/pdf/factsheets/omega3fattyacids-consumer.pdf

17 Science-Based Benefits of Omega-3 Fatty Acids
https://www.healthline.com/nutrition/17-health-benefits-of-omega-3

Omega-3 fatty acids EPA and DHA: health benefits throughout life
Studies have shown that EPA and DHA are important for proper fetal development, including neuronal, retinal, and immune function. EPA and DHA may affect many aspects of cardiovascular function including inflammation, peripheral artery disease, major coronary events, and anticoagulation. EPA and DHA have been linked to promising results in prevention, weight management, and cognitive function in those with very mild Alzheimer's disease. 
https://pubmed.ncbi.nlm.nih.gov/22332096/

Therapeutic Effect of EPA/DHA Supplementation in Neoplastic and Non-neoplastic Companion Animal Diseases: A Systematic Review

https://pubmed.ncbi.nlm.nih.gov/33910819/

Exploring the efficacy and optimal dosages of omega-3 supplementation for companion animals with chronic diseases

https://pubmed.ncbi.nlm.nih.gov/40495687/

Therapeutic use of fish oils in companion animals

https://pubmed.ncbi.nlm.nih.gov/22087720/

The essential nature of dietary omega-3 fatty acids in dogs

https://pubmed.ncbi.nlm.nih.gov/27875089/

Potential adverse effects of omega-3 fatty acids in dogs and cats

https://pubmed.ncbi.nlm.nih.gov/23323770/

General Research References

Pubmed EPA Treatment Research Summary
https://pubmed.ncbi.nlm.nih.gov/?term=Eicosapentaenoic+Acid+%28EPA%29&filter=pubt.review

Muller and Kirk's Small Animal Dermatology - 9781416000280
https://www.elsevier.com/books/muller-and-kirks-small-animal-dermatology/miller/978-1-4160-0028-0

Small Animal Dermatology - 9780323376518
https://www.us.elsevierhealth.com/small-animal-dermatology-9780323376518.html

Omega-3 Fatty Acids Fact Sheet
https://ods.od.nih.gov/pdf/factsheets/omega3fattyacids-consumer.pdf

17 Science-Based Benefits of Omega-3 Fatty Acids
https://www.healthline.com/nutrition/17-health-benefits-of-omega-3

Omega-3 fatty acids EPA and DHA: health benefits throughout life
Studies have shown that EPA and DHA are important for proper fetal development, including neuronal, retinal, and immune function. EPA and DHA may affect many aspects of cardiovascular function including inflammation, peripheral artery disease, major coronary events, and anticoagulation. EPA and DHA have been linked to promising results in prevention, weight management, and cognitive function in those with very mild Alzheimer's disease. 
https://pubmed.ncbi.nlm.nih.gov/22332096/

Therapeutic Effect of EPA/DHA Supplementation in Neoplastic and Non-neoplastic Companion Animal Diseases: A Systematic Review

https://pubmed.ncbi.nlm.nih.gov/33910819/

Exploring the efficacy and optimal dosages of omega-3 supplementation for companion animals with chronic diseases

https://pubmed.ncbi.nlm.nih.gov/40495687/

Therapeutic use of fish oils in companion animals

https://pubmed.ncbi.nlm.nih.gov/22087720/

The essential nature of dietary omega-3 fatty acids in dogs

https://pubmed.ncbi.nlm.nih.gov/27875089/

Potential adverse effects of omega-3 fatty acids in dogs and cats

https://pubmed.ncbi.nlm.nih.gov/23323770/

Anti-Inflammatory & Joint Health Benefits

References

Effects of dietary supplementation with fish oil on in vivo production of inflammatory mediators in clinically normal dogs
Results supported the use of EPA- and DHA-enriched diets as part of antiinflammatory treatments for dogs with chronic inflammatory diseases.
https://pubmed.ncbi.nlm.nih.gov/18380580/

Canine plasma and erythrocyte response to a docosahexaenoic acid-enriched supplement: characterization and potential benefits
Studies describing some of the neurologic, renal, cardiovascular, immune, and musculoskeletal effects of elevated blood levels of n-3 fatty acids are reviewed.

https://pubmed.ncbi.nlm.nih.gov/15906268/

A prospective, randomized, double blind, placebo-controlled evaluation of the effects of eicosapentaenoic acid and docosahexaenoic acid on the clinical signs and erythrocyte membrane polyunsaturated fatty acid concentrations in dogs with osteoarthritis
This study demonstrated that the daily supplementation of a dogs diet with EPA and DHA shifts the blood fatty acid concentrations correlating to relief of clinical signs associated with OA in dogs. 
https://pubmed.ncbi.nlm.nih.gov/27269707/

Evaluation of the effects of dietary supplementation with fish oil omega-3 fatty acids on weight bearing in dogs with osteoarthritis

https://pubmed.ncbi.nlm.nih.gov/20043801/

A multicenter study of the effect of dietary supplementation with fish oil omega-3 fatty acids on carprofen dosage in dogs with osteoarthritis

https://pubmed.ncbi.nlm.nih.gov/20187817/

Dose-titration effects of fish oil in osteoarthritic dogs

https://pubmed.ncbi.nlm.nih.gov/20707845/

A prospective, randomized, double blind, placebo-controlled evaluation of EPA and DHA in dogs with osteoarthritis

https://pubmed.ncbi.nlm.nih.gov/27269707/

The effect of dietary long-chain omega-3 fatty acid supplementation on owner perception of behaviour and locomotion in cats with naturally occurring osteoarthritis

https://pubmed.ncbi.nlm.nih.gov/22882740/

Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance

https://pubmed.ncbi.nlm.nih.gov/25149823/

Omega-3 fatty acids and inflammatory processes: from molecules to man

https://pubmed.ncbi.nlm.nih.gov/28900017/

Omega-3 fatty acids and inflammatory processes

https://pubmed.ncbi.nlm.nih.gov/22254027/

Effects of omega-3 supplementation on lipid metabolism and clinical symptoms in rheumatoid arthritis: a systematic review/meta-analysis

https://pubmed.ncbi.nlm.nih.gov/38922552/

A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain

https://pubmed.ncbi.nlm.nih.gov/17335973/

Omega-3 polyunsaturated fatty acids and the treatment of rheumatoid arthritis: a meta-analysis

https://pubmed.ncbi.nlm.nih.gov/22835600/

References

Effects of dietary supplementation with fish oil on in vivo production of inflammatory mediators in clinically normal dogs
Results supported the use of EPA- and DHA-enriched diets as part of antiinflammatory treatments for dogs with chronic inflammatory diseases.
https://pubmed.ncbi.nlm.nih.gov/18380580/

Canine plasma and erythrocyte response to a docosahexaenoic acid-enriched supplement: characterization and potential benefits
Studies describing some of the neurologic, renal, cardiovascular, immune, and musculoskeletal effects of elevated blood levels of n-3 fatty acids are reviewed.

https://pubmed.ncbi.nlm.nih.gov/15906268/

A prospective, randomized, double blind, placebo-controlled evaluation of the effects of eicosapentaenoic acid and docosahexaenoic acid on the clinical signs and erythrocyte membrane polyunsaturated fatty acid concentrations in dogs with osteoarthritis
This study demonstrated that the daily supplementation of a dogs diet with EPA and DHA shifts the blood fatty acid concentrations correlating to relief of clinical signs associated with OA in dogs. 
https://pubmed.ncbi.nlm.nih.gov/27269707/

Evaluation of the effects of dietary supplementation with fish oil omega-3 fatty acids on weight bearing in dogs with osteoarthritis

https://pubmed.ncbi.nlm.nih.gov/20043801/

A multicenter study of the effect of dietary supplementation with fish oil omega-3 fatty acids on carprofen dosage in dogs with osteoarthritis

https://pubmed.ncbi.nlm.nih.gov/20187817/

Dose-titration effects of fish oil in osteoarthritic dogs

https://pubmed.ncbi.nlm.nih.gov/20707845/

A prospective, randomized, double blind, placebo-controlled evaluation of EPA and DHA in dogs with osteoarthritis

https://pubmed.ncbi.nlm.nih.gov/27269707/

The effect of dietary long-chain omega-3 fatty acid supplementation on owner perception of behaviour and locomotion in cats with naturally occurring osteoarthritis

https://pubmed.ncbi.nlm.nih.gov/22882740/

Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance

https://pubmed.ncbi.nlm.nih.gov/25149823/

Omega-3 fatty acids and inflammatory processes: from molecules to man

https://pubmed.ncbi.nlm.nih.gov/28900017/

Omega-3 fatty acids and inflammatory processes

https://pubmed.ncbi.nlm.nih.gov/22254027/

Effects of omega-3 supplementation on lipid metabolism and clinical symptoms in rheumatoid arthritis: a systematic review/meta-analysis

https://pubmed.ncbi.nlm.nih.gov/38922552/

A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain

https://pubmed.ncbi.nlm.nih.gov/17335973/

Omega-3 polyunsaturated fatty acids and the treatment of rheumatoid arthritis: a meta-analysis

https://pubmed.ncbi.nlm.nih.gov/22835600/

Immune & Heart Support Benefits

References

Effects of Omega-3 Fatty Acids on Immune Cells - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834330/

Omega-3 backed to boost immune response, not just battle inflammation: Study
https://www.nutraingredients.com/Article/2013/04/02/Omega-3-backed-to-boost-immune-health-not-just-battle-inflammation

Effect of omega-3 fatty acids on cardiovascular outcomes: A systematic review and meta-analysis
Omega-3 FAs reduced cardiovascular mortality and improved cardiovascular outcomes. The cardiovascular risk reduction was more prominent with EPA monotherapy than with EPA+DHA. 
https://pubmed.ncbi.nlm.nih.gov/34505026/

Beneficial effects of omega-3 fatty acids in cardiovascular disease

https://pubmed.ncbi.nlm.nih.gov/20673293/

Omega-3 Fatty Acids for the Management of Hypertriglyceridemia: A Science Advisory From the American Heart Association

https://pubmed.ncbi.nlm.nih.gov/31422671/

Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia

https://pubmed.ncbi.nlm.nih.gov/30415628/

Effects of Icosapent Ethyl on Total Ischemic Events

https://pubmed.ncbi.nlm.nih.gov/30898607/

Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events

https://pubmed.ncbi.nlm.nih.gov/33190147/

Effect of omega-3 fatty acids on cardiovascular outcomes: a systematic review and meta-analysis

https://pmc.ncbi.nlm.nih.gov/articles/PMC8413259/

Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease

https://pubmed.ncbi.nlm.nih.gov/30019766/

References

Effects of Omega-3 Fatty Acids on Immune Cells - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834330/

Omega-3 backed to boost immune response, not just battle inflammation: Study
https://www.nutraingredients.com/Article/2013/04/02/Omega-3-backed-to-boost-immune-health-not-just-battle-inflammation

Effect of omega-3 fatty acids on cardiovascular outcomes: A systematic review and meta-analysis
Omega-3 FAs reduced cardiovascular mortality and improved cardiovascular outcomes. The cardiovascular risk reduction was more prominent with EPA monotherapy than with EPA+DHA. 
https://pubmed.ncbi.nlm.nih.gov/34505026/

Beneficial effects of omega-3 fatty acids in cardiovascular disease

https://pubmed.ncbi.nlm.nih.gov/20673293/

Omega-3 Fatty Acids for the Management of Hypertriglyceridemia: A Science Advisory From the American Heart Association

https://pubmed.ncbi.nlm.nih.gov/31422671/

Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia

https://pubmed.ncbi.nlm.nih.gov/30415628/

Effects of Icosapent Ethyl on Total Ischemic Events

https://pubmed.ncbi.nlm.nih.gov/30898607/

Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events

https://pubmed.ncbi.nlm.nih.gov/33190147/

Effect of omega-3 fatty acids on cardiovascular outcomes: a systematic review and meta-analysis

https://pmc.ncbi.nlm.nih.gov/articles/PMC8413259/

Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease

https://pubmed.ncbi.nlm.nih.gov/30019766/

Skin, Gland, Allergy & Dry Eye Support Benefits

References

The Potential Uses of Omega-3 Fatty Acids in Dermatology: A Review
https://journals.sagepub.com/doi/10.1177/1203475420929925


Essential Fatty Acids for Integumentary Disease in Animals - Pharmacology - Merck Veterinary Manual
Omega-3 fatty acids can potentially help dogs with allergies by reducing inflammation and improving the overall health of their skin and coat. Allergies in dogs can manifest in various ways, including skin irritation, itching, and inflammation, and omega-3s may help alleviate these symptoms.
https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-integumentary-system/essential-fatty-acids-for-integumentary-disease-in-animals

Lipid mediators have important roles for the pathophysiology of the allergic diseases
https://pubmed.ncbi.nlm.nih.gov/31465315/

Oral omega 3 in different proportions of EPA, DHA, and antioxidants as adjuvant in treatment of keratoconjunctivitis sicca (dry eye) in dogs
https://pubmed.ncbi.nlm.nih.gov/30208145/

Effect of omega-3 fatty acids on canine atopic dermatitis

https://pubmed.ncbi.nlm.nih.gov/15206474/

A randomized, controlled study to evaluate the steroid-sparing effect of essential fatty acid supplementation in canine atopic dermatitis

https://pubmed.ncbi.nlm.nih.gov/15214949/

Evaluation of cyclosporine-sparing effects of polyunsaturated fatty acids in the treatment of canine atopic dermatitis

https://pubmed.ncbi.nlm.nih.gov/26975448/

A prospective, randomized, double blind, placebo-controlled evaluation of the effects of an n-3 essential fatty acids supplement on clinical signs, fatty acid concentrations, hair shafts and skin surface of dogs with poor quality coats

https://pubmed.ncbi.nlm.nih.gov/32505998/

Beneficial effects of chronic administration of dietary omega-3 polyunsaturated fatty acids in dogs with renal insufficiency

https://pubmed.ncbi.nlm.nih.gov/9605110/

Effect of fish oil, arginine, and doxorubicin chemotherapy on remission and survival time for dogs with lymphoma: a double-blind, randomized placebo-controlled study

https://pubmed.ncbi.nlm.nih.gov/10760770/

Omega-3 and omega-6 polyunsaturated fatty acids for dry eye disease

https://pubmed.ncbi.nlm.nih.gov/31847055/

Efficacy of Omega-3 Intake in Managing Dry Eye Disease: A Systematic Review and Meta-analysis

https://pubmed.ncbi.nlm.nih.gov/38002640/

The Potential Uses of Omega-3 Fatty Acids in Dermatology: A Review

https://pubmed.ncbi.nlm.nih.gov/32463305/

Cosmetic and Therapeutic Applications of Fish Oil’s Fatty Acids on the Skin

https://pubmed.ncbi.nlm.nih.gov/30061538/

Impact of n-3 polyunsaturated fatty acid supplementation on visual health throughout the life cycle: A systematic review

https://pubmed.ncbi.nlm.nih.gov/40499235/

References

The Potential Uses of Omega-3 Fatty Acids in Dermatology: A Review
https://journals.sagepub.com/doi/10.1177/1203475420929925


Essential Fatty Acids for Integumentary Disease in Animals - Pharmacology - Merck Veterinary Manual
Omega-3 fatty acids can potentially help dogs with allergies by reducing inflammation and improving the overall health of their skin and coat. Allergies in dogs can manifest in various ways, including skin irritation, itching, and inflammation, and omega-3s may help alleviate these symptoms.
https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-integumentary-system/essential-fatty-acids-for-integumentary-disease-in-animals

Lipid mediators have important roles for the pathophysiology of the allergic diseases
https://pubmed.ncbi.nlm.nih.gov/31465315/

Oral omega 3 in different proportions of EPA, DHA, and antioxidants as adjuvant in treatment of keratoconjunctivitis sicca (dry eye) in dogs
https://pubmed.ncbi.nlm.nih.gov/30208145/

Effect of omega-3 fatty acids on canine atopic dermatitis

https://pubmed.ncbi.nlm.nih.gov/15206474/

A randomized, controlled study to evaluate the steroid-sparing effect of essential fatty acid supplementation in canine atopic dermatitis

https://pubmed.ncbi.nlm.nih.gov/15214949/

Evaluation of cyclosporine-sparing effects of polyunsaturated fatty acids in the treatment of canine atopic dermatitis

https://pubmed.ncbi.nlm.nih.gov/26975448/

A prospective, randomized, double blind, placebo-controlled evaluation of the effects of an n-3 essential fatty acids supplement on clinical signs, fatty acid concentrations, hair shafts and skin surface of dogs with poor quality coats

https://pubmed.ncbi.nlm.nih.gov/32505998/

Beneficial effects of chronic administration of dietary omega-3 polyunsaturated fatty acids in dogs with renal insufficiency

https://pubmed.ncbi.nlm.nih.gov/9605110/

Effect of fish oil, arginine, and doxorubicin chemotherapy on remission and survival time for dogs with lymphoma: a double-blind, randomized placebo-controlled study

https://pubmed.ncbi.nlm.nih.gov/10760770/

Omega-3 and omega-6 polyunsaturated fatty acids for dry eye disease

https://pubmed.ncbi.nlm.nih.gov/31847055/

Efficacy of Omega-3 Intake in Managing Dry Eye Disease: A Systematic Review and Meta-analysis

https://pubmed.ncbi.nlm.nih.gov/38002640/

The Potential Uses of Omega-3 Fatty Acids in Dermatology: A Review

https://pubmed.ncbi.nlm.nih.gov/32463305/

Cosmetic and Therapeutic Applications of Fish Oil’s Fatty Acids on the Skin

https://pubmed.ncbi.nlm.nih.gov/30061538/

Impact of n-3 polyunsaturated fatty acid supplementation on visual health throughout the life cycle: A systematic review

https://pubmed.ncbi.nlm.nih.gov/40499235/

Brain & Mental Health Support Benefits

References

EPA but not DHA appears to be responsible for the efficacy of omega-3 long chain polyunsaturated fatty acid supplementation in depression: evidence from a meta-analysis of randomized controlled trials
The current meta-analysis provides evidence that EPA may be more efficacious than DHA in treating depression. 
https://pubmed.ncbi.nlm.nih.gov/20439549/

International Society for Nutritional Psychiatry Research Practice Guidelines for Omega-3 Fatty Acids in the Treatment of Major Depressive Disorder
https://pubmed.ncbi.nlm.nih.gov/31480057/

The differential effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on seizure frequency in patients with drug-resistant epilepsy - A randomized, double-blind, placebo-controlled trial
This study demonstrates that EPA and DHA are effective in reducing seizure frequency in patients with DRE. 
https://pubmed.ncbi.nlm.nih.gov/30170260/

Efficacy of omega-3 PUFAs in depression: A meta-analysis

https://pubmed.ncbi.nlm.nih.gov/31383846/

Meta-analysis of the effects of eicosapentaenoic acid in clinical trials in depression

https://pubmed.ncbi.nlm.nih.gov/21939614/

Efficacy of omega-3 highly unsaturated fatty acids in the treatment of depression

https://pubmed.ncbi.nlm.nih.gov/27103682/

Omega-3 fatty acids and cognitive function

https://pubmed.ncbi.nlm.nih.gov/36637075/

References

EPA but not DHA appears to be responsible for the efficacy of omega-3 long chain polyunsaturated fatty acid supplementation in depression: evidence from a meta-analysis of randomized controlled trials
The current meta-analysis provides evidence that EPA may be more efficacious than DHA in treating depression. 
https://pubmed.ncbi.nlm.nih.gov/20439549/

International Society for Nutritional Psychiatry Research Practice Guidelines for Omega-3 Fatty Acids in the Treatment of Major Depressive Disorder
https://pubmed.ncbi.nlm.nih.gov/31480057/

The differential effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on seizure frequency in patients with drug-resistant epilepsy - A randomized, double-blind, placebo-controlled trial
This study demonstrates that EPA and DHA are effective in reducing seizure frequency in patients with DRE. 
https://pubmed.ncbi.nlm.nih.gov/30170260/

Efficacy of omega-3 PUFAs in depression: A meta-analysis

https://pubmed.ncbi.nlm.nih.gov/31383846/

Meta-analysis of the effects of eicosapentaenoic acid in clinical trials in depression

https://pubmed.ncbi.nlm.nih.gov/21939614/

Efficacy of omega-3 highly unsaturated fatty acids in the treatment of depression

https://pubmed.ncbi.nlm.nih.gov/27103682/

Omega-3 fatty acids and cognitive function

https://pubmed.ncbi.nlm.nih.gov/36637075/

Cancer Prevention Benefits

References

Therapeutic Effect of EPA/DHA Supplementation in Neoplastic and Non-neoplastic Companion Animal Diseases: A Systematic Review
EPA; Eicosapentaenoic acid; cats; docosahexaenoic acid; dogs; omega-3 fatty acids; review; supplementation. 
https://pubmed.ncbi.nlm.nih.gov/33910819/

Therapeutic Effect of EPA/DHA Supplementation in Neoplastic and Non-neoplastic Companion Animal Diseases: A Systematic Review
EPA and DHA supplementation has proven benefits in the adjuvant treatment of various neoplastic and non-neoplastic diseases in dogs and cats.

https://pubmed.ncbi.nlm.nih.gov/33910819/

References

Therapeutic Effect of EPA/DHA Supplementation in Neoplastic and Non-neoplastic Companion Animal Diseases: A Systematic Review
EPA; Eicosapentaenoic acid; cats; docosahexaenoic acid; dogs; omega-3 fatty acids; review; supplementation. 
https://pubmed.ncbi.nlm.nih.gov/33910819/

Therapeutic Effect of EPA/DHA Supplementation in Neoplastic and Non-neoplastic Companion Animal Diseases: A Systematic Review
EPA and DHA supplementation has proven benefits in the adjuvant treatment of various neoplastic and non-neoplastic diseases in dogs and cats.

https://pubmed.ncbi.nlm.nih.gov/33910819/