Active Ingredient Research
Lactobacillus Sakei Probio-65
First found in Kimchi & used for hundreds of years to speed immune system & gut recovery.
Research Overview
Probiotics are all natural holistic nutraceuticals with clinically proven medical benefits.
Immune-mediated inflammatory diseases are associated with an abnormal immune response, resulting in a disturbed homeostasis and chronic inflammation.
Using the CORRECT probiotic leverages beneficial microorganisms that can positively influence the host's health when consumed in adequate amounts. Benefits include:
Recovery of homeostasis
Recover gut and skin health
Restore “GOOD” bacteria
Replenish the healthy balance of bacteria
Reduce inflammation: allergy and arthritis
Reduce GI tract inflammation
Decrease skin and ear infections by restoring healthy microbiome
Improve healthy nutrient absorption
General Research References
Evidence-base for the beneficial effect of nutraceuticals in canine dermatological immune-mediated inflammatory diseases - A literature review. Vet Dermatol. 2023 Aug;34(4):266-283. doi: 10.1111/vde.13152. Epub 2023 Mar 20.
https://pubmed.ncbi.nlm.nih.gov/36938651/
General References
Evidence-base for the beneficial effect of nutraceuticals in canine dermatological immune-mediated inflammatory diseases - A literature review. Vet Dermatol. 2023 Aug;34(4):266-283. doi: 10.1111/vde.13152. Epub 2023 Mar 20.
https://pubmed.ncbi.nlm.nih.gov/36938651/
General Research References
Evidence-base for the beneficial effect of nutraceuticals in canine dermatological immune-mediated inflammatory diseases - A literature review. Vet Dermatol. 2023 Aug;34(4):266-283. doi: 10.1111/vde.13152. Epub 2023 Mar 20.
https://pubmed.ncbi.nlm.nih.gov/36938651/
Dosage References
Lactobacillus sakei probio-65 2gram (4x109 cfu) per 20lbs body weight
1 chew per 20 lbs each day
A Double-Blind, Placebo Controlled-Trial of a Probiotic Strain Lactobacillus sakei Probio-65 for the Prevention of Canine Atopic Dermatitis. J Microbiol Biotechnol. 2015 Nov;25(11):1966-9.
https://pubmed.ncbi.nlm.nih.gov/26282691/
Dosage References
Lactobacillus sakei probio-65 2gram (4x109 cfu) per 20lbs body weight
1 chew per 20 lbs each day
A Double-Blind, Placebo Controlled-Trial of a Probiotic Strain Lactobacillus sakei Probio-65 for the Prevention of Canine Atopic Dermatitis. J Microbiol Biotechnol. 2015 Nov;25(11):1966-9.
https://pubmed.ncbi.nlm.nih.gov/26282691/
Dosage References
Lactobacillus sakei probio-65 2gram (4x109 cfu) per 20lbs body weight
1 chew per 20 lbs each day
A Double-Blind, Placebo Controlled-Trial of a Probiotic Strain Lactobacillus sakei Probio-65 for the Prevention of Canine Atopic Dermatitis. J Microbiol Biotechnol. 2015 Nov;25(11):1966-9.
https://pubmed.ncbi.nlm.nih.gov/26282691/
Reduce Chronic Inflammation (Allergy) Benefits
References
A Double-Blind, Placebo Controlled-Trial of a Probiotic Strain Lactobacillus sakei Probio-65 for the Prevention of Canine Atopic Dermatitis. J Microbiol Biotechnol. 2015 Nov;25(11):1966-9.
https://pubmed.ncbi.nlm.nih.gov/26282691/
References
A Double-Blind, Placebo Controlled-Trial of a Probiotic Strain Lactobacillus sakei Probio-65 for the Prevention of Canine Atopic Dermatitis. J Microbiol Biotechnol. 2015 Nov;25(11):1966-9.
https://pubmed.ncbi.nlm.nih.gov/26282691/
References
A Double-Blind, Placebo Controlled-Trial of a Probiotic Strain Lactobacillus sakei Probio-65 for the Prevention of Canine Atopic Dermatitis. J Microbiol Biotechnol. 2015 Nov;25(11):1966-9.
https://pubmed.ncbi.nlm.nih.gov/26282691/
Prevent Canine Allergy Benefits
References
A Double-Blind, Placebo Controlled-Trial of a Probiotic Strain Lactobacillus sakei Probio-65 for the Prevention of Canine Atopic Dermatitis. J Microbiol Biotechnol. 2015 Nov;25(11):1966-9.
https://pubmed.ncbi.nlm.nih.gov/26282691/
Probiotics for the treatment or prevention of atopic dermatitis: a review of the evidence from randomized controlled trials. Am J Clin Dermatol. 2008;9(2):93-103.
https://pubmed.ncbi.nlm.nih.gov/18284263/
References
A Double-Blind, Placebo Controlled-Trial of a Probiotic Strain Lactobacillus sakei Probio-65 for the Prevention of Canine Atopic Dermatitis. J Microbiol Biotechnol. 2015 Nov;25(11):1966-9.
https://pubmed.ncbi.nlm.nih.gov/26282691/
Probiotics for the treatment or prevention of atopic dermatitis: a review of the evidence from randomized controlled trials. Am J Clin Dermatol. 2008;9(2):93-103.
https://pubmed.ncbi.nlm.nih.gov/18284263/
References
A Double-Blind, Placebo Controlled-Trial of a Probiotic Strain Lactobacillus sakei Probio-65 for the Prevention of Canine Atopic Dermatitis. J Microbiol Biotechnol. 2015 Nov;25(11):1966-9.
https://pubmed.ncbi.nlm.nih.gov/26282691/
Probiotics for the treatment or prevention of atopic dermatitis: a review of the evidence from randomized controlled trials. Am J Clin Dermatol. 2008;9(2):93-103.
https://pubmed.ncbi.nlm.nih.gov/18284263/
Improve Skin Lesions and Allergy Inflammation Benefits
References
Atopic dermatitis-mitigating effects of new Lactobacillus strain, Lactobacillus sakei probio 65 isolated from Kimchi. J Appl Microbiol. 2013 Aug;115(2):517-26. doi: 10.1111/jam.12229. Epub 2013 May 16.
https://pubmed.ncbi.nlm.nih.gov/23607518/
References
Atopic dermatitis-mitigating effects of new Lactobacillus strain, Lactobacillus sakei probio 65 isolated from Kimchi. J Appl Microbiol. 2013 Aug;115(2):517-26. doi: 10.1111/jam.12229. Epub 2013 May 16.
https://pubmed.ncbi.nlm.nih.gov/23607518/
References
Atopic dermatitis-mitigating effects of new Lactobacillus strain, Lactobacillus sakei probio 65 isolated from Kimchi. J Appl Microbiol. 2013 Aug;115(2):517-26. doi: 10.1111/jam.12229. Epub 2013 May 16.
https://pubmed.ncbi.nlm.nih.gov/23607518/
Treats Allergy and Psoriasis; Antibodies (IgE) and Inflammation Chemicals in mouse-model studies Benefits
References
New functional probiotic Lactobacillus sakei probio 65 alleviates atopic symptoms in the mouse. J Med Food. 2008 Sep;11(3):405-12.
https://pubmed.ncbi.nlm.nih.gov/18800885/
Probiotic Lactobacillus sakei proBio-65 Extract Ameliorates the Severity of Imiquimod Induced Psoriasis-Like Skin Inflammation in a Mouse Model. Front Microbiol. 2018 May 17:9:1021. doi: 10.3389/fmicb.2018.01021. eCollection 2018.
https://pubmed.ncbi.nlm.nih.gov/29867905/
References
New functional probiotic Lactobacillus sakei probio 65 alleviates atopic symptoms in the mouse. J Med Food. 2008 Sep;11(3):405-12.
https://pubmed.ncbi.nlm.nih.gov/18800885/
Probiotic Lactobacillus sakei proBio-65 Extract Ameliorates the Severity of Imiquimod Induced Psoriasis-Like Skin Inflammation in a Mouse Model. Front Microbiol. 2018 May 17:9:1021. doi: 10.3389/fmicb.2018.01021. eCollection 2018.
https://pubmed.ncbi.nlm.nih.gov/29867905/
References
New functional probiotic Lactobacillus sakei probio 65 alleviates atopic symptoms in the mouse. J Med Food. 2008 Sep;11(3):405-12.
https://pubmed.ncbi.nlm.nih.gov/18800885/
Probiotic Lactobacillus sakei proBio-65 Extract Ameliorates the Severity of Imiquimod Induced Psoriasis-Like Skin Inflammation in a Mouse Model. Front Microbiol. 2018 May 17:9:1021. doi: 10.3389/fmicb.2018.01021. eCollection 2018.
https://pubmed.ncbi.nlm.nih.gov/29867905/
Relieve Constipation Benefits
References
Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial
Dietary fibers/probiotics may relieve constipation via optimizing gut microbiome: In conclusion, we found that the dietary fibers or probiotics may relieve hard stool, with intervention-specific changes in gut microbiota relevant to constipation relief.
Gut Microbes. 2023 Jan-Dec;15(1):2197837. doi: 10.1080/19490976.2023.2197837.
https://pubmed.ncbi.nlm.nih.gov/37078654/
References
Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial
Dietary fibers/probiotics may relieve constipation via optimizing gut microbiome: In conclusion, we found that the dietary fibers or probiotics may relieve hard stool, with intervention-specific changes in gut microbiota relevant to constipation relief.
Gut Microbes. 2023 Jan-Dec;15(1):2197837. doi: 10.1080/19490976.2023.2197837.
https://pubmed.ncbi.nlm.nih.gov/37078654/
References
Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial
Dietary fibers/probiotics may relieve constipation via optimizing gut microbiome: In conclusion, we found that the dietary fibers or probiotics may relieve hard stool, with intervention-specific changes in gut microbiota relevant to constipation relief.
Gut Microbes. 2023 Jan-Dec;15(1):2197837. doi: 10.1080/19490976.2023.2197837.
https://pubmed.ncbi.nlm.nih.gov/37078654/